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C-type lectin receptor

" in MedChemExpress (MCE) Product Catalog:

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7

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Cat. No. Compare Product Name Species Source
  • HY-P700694
    Dectin-1/CLEC7A Protein, Mouse (HEK293, Fc)

    Beta-glucan receptor; DC-associated C-type lectin 1; Dectin-1; Dectin1; CD369; BGR; CLECSF12; DECTIN1; CANDF4

    		 Mouse HEK293
    Dectin-1/CLEC7A acts as a lectin and specifically recognizes β-1,3-linked and β-1,6-linked glucans in bacterial and fungal cell walls. Dectin-1/CLEC7A is critical for Toll-like receptor 2 (TLR2)-mediated inflammation by recruiting SYK through its immunoreceptor tyrosine-based activation motif (ITAM), thereby activating NF-kappa-B. Dectin-1/CLEC7A Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Dectin-1/CLEC7A protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Dectin-1/CLEC7A Protein, Mouse (HEK293, Fc) is 174 a.a., with molecular weight of 50-65 kDa.
  • HY-P77901
    OCIL/CLEC2D Protein, Human (HEK293, Fc-Avi)

    C-type lectin domain family 2 member D; lectin-like NK cell receptor; lectin-like transcript 1; LLT-1; CLAX; LLT1; OCIL; CLEC2D

    		 Human HEK293
    OCIL/CLEC2D Protein, as a receptor for KLRB1, safeguards target cells from natural killer cell-mediated lysis. It not only inhibits osteoclast formation and bone resorption but also regulates interferon-gamma release, indicating its immune and bone-related regulatory functions. Additionally, OCIL/CLEC2D can bind high molecular weight sulfated glycosaminoglycans, suggesting its involvement in interactions with extracellular components. Existing as a homodimer with disulfide linkages, its oligomeric form plays a crucial role in mediating immune protection and bone homeostasis. OCIL/CLEC2D Protein, Human (HEK293, Fc-Avi) is the recombinant human-derived OCIL/CLEC2D protein, expressed by HEK293, with N-hFc, N-Avi labeled tag. The total length of OCIL/CLEC2D Protein, Human (HEK293, Fc-Avi) is 132 a.a., with molecular weight of 68-78 kDa.
  • HY-P75677
    CLEC4F/CLECSF13 Protein, Mouse (HEK293, Fc)

    C-type lectin domain family 4 member F; C-type lectin 13; Kupffer cell receptor; Kclr

    		 Mouse HEK293
    CLEC4F/CLECSF13 protein, a receptor with a distinct affinity for galactose and fucose, suggests involvement in endocytosis. With a binding preference for these carbohydrates, it plays a role in recognizing and potentially internalizing cellular components. CLEC4F/CLECSF13's implication in endocytosis highlights its significance in cellular uptake mechanisms, hinting at potential contributions to various physiological processes. CLEC4F/CLECSF13 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CLEC4F/CLECSF13 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC4F/CLECSF13 Protein, Mouse (HEK293, Fc) is 479 a.a., with molecular weight of ~82.1 kDa.
  • HY-P71749
    KLRG2 Protein, Human (P.pastoris, His)

    KLRG2; CLEC15B; Killer cell lectin-like receptor subfamily G member 2; C-type lectin domain family 15 member B

    		 Human P. pastoris
    KLRG2 Protein is a member of the killer cell lectin-like receptor (KLR) family, is a group of transmembrane proteins preferentially expressed in NK cells. Genetic variations in the gene KLRG2 may affect the Gleason score at diagnosis and thus the aggressiveness of prostate cancer. KLRG2 Protein, Human (P.pastoris, His) is the recombinant human-derived KLRG2 protein, expressed by P. pastoris , with N-His labeled tag. The total length of KLRG2 Protein, Human (P.pastoris, His) is 409 a.a., with molecular weight of ~44.9 kDa.
  • HY-P700875
    MRC2 Protein, Human (HEK293, His)

    C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein (UPAR-associated protein; Urokinase receptor-associated protein)

    		 Human HEK293
    MRC2 Protein potentially acts as an endocytotic lectin receptor with calcium-dependent lectin activity. It internalizes glycosylated ligands through clathrin-mediated endocytosis, releasing them in endosomes. MRC2 may control PLAUR/PLAU levels in the plasminogen activation system, regulating cell surface protease activity. It contributes to cellular uptake, remodeling, and degradation of extracellular collagen matrices, influencing collagen turnover in cancer and tissue destructive diseases. MRC2 collaborates with matrix metalloproteinases, interacting with type I collagen, forming a tri-molecular complex with PLAUR/UPAR and PLAU/pro-UPA, and directly engaging with collagen V, highlighting its versatile role in cellular processes related to extracellular matrix dynamics. MRC2 Protein, Human (HEK293, His) is the recombinant human-derived MRC2 protein, expressed by HEK293, with C-His labeled tag. The total length of MRC2 Protein, Human (HEK293, His) is 500 a.a., with molecular weight of 65-75 kDa.
  • HY-P71180
    OLR1 Protein, Human (HEK293, His)

    Oxidized Low-Density Lipoprotein receptor 1; Ox-LDL receptor 1; C-type lectin Domain Family 8 Member A; lectin-Like Oxidized LDL receptor 1; LOX-1; lectin-Like oxLDL receptor 1; hLOX-1; lectin-type Oxidized LDL receptor 1; OLR1; CLEC8A; LOX1

    		Human HEK293
    OLR1 Protein, a receptor on vascular endothelial cells, plays a key role in recognizing, internalizing, and degrading oxidatively modified low-density lipoprotein (oxLDL). As a marker of atherosclerosis, oxLDL induces vascular endothelial cell activation, leading to pro-inflammatory responses, oxidative conditions, and apoptosis. OLR1's association with oxLDL activates NF-kappa-B, contributing to pro-atherogenic responses such as reduced nitric oxide release, monocyte adhesion, and apoptosis. Beyond oxLDL, it serves as a receptor for HSP70, participating in cell-mediated antigen cross-presentation and functioning as a leukocyte-adhesion molecule in inflammation. Additionally, OLR1 recognizes AGE products, activated platelets, monocytes, apoptotic cells, and bacteria. OLR1 Protein, Human (HEK293, His) is the recombinant human-derived OLR1 protein, expressed by HEK293, with C-6*His labeled tag. The total length of OLR1 Protein, Human (HEK293, His) is 213 a.a., with molecular weight of 30-35 kDa.
  • HY-P70101
    Dectin-1/CLEC7A Protein, Human (HEK293, Fc)
    1 Publications Verification

    rHuC-type lectin domain family 7 member A/Dectin-1, Fc; Beta-glucan receptor; BGR; CD369; CLEC7A; CLECSF12; CLECSF12DC-associated C-type lectin 1; Dectin1; Dectin-1; DECTIN1CANDF4

    		 Human HEK293
    The Dectin-1/CLEC7A protein is a lectin and pattern recognition receptor that targets β-1,3- and β-1,6-linked glucans in bacterial and fungal cell walls. It triggers Toll-like receptor 2 (TLR2)-mediated inflammation by recruiting splenic tyrosine kinase (SYK) and activating the CARD domain-BCL10-MALT1 (CBM) signalosome. Dectin-1/CLEC7A Protein, Human (HEK293, Fc) is the recombinant human-derived Dectin-1/CLEC7A protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Dectin-1/CLEC7A Protein, Human (HEK293, Fc) is 182 a.a., with molecular weight of 50-65 kDa.

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